Patient handout
Trazodone
You have been prescribed trazodone. This page explains what it is, what to expect, and when to call.
What it is
Trazodone is an antidepressant that, at low doses, is used mainly to help with sleep. It is not habit-forming and does not lose its effect over time the way many sleep aids do. At higher doses it treats depression.
How to take it
- Take it thirty to sixty minutes before bedtime, with a light snack to reduce dizziness.
- Plan for seven to eight hours in bed so you are not groggy in the morning.
- If you miss a dose, skip it. Do not take it late at night or double up.
- Do not drive after taking it.
What to expect, and when
- Most people fall asleep more easily from the first few nights.
- Morning grogginess is common in the first week and usually fades.
- If the dose is too low to help or leaves you groggy, tell us; small adjustments make a big difference.
- It works best alongside good sleep habits. The CBT-I guide on our site explains them.
Common side effects
Drowsiness, dizziness or lightheadedness when standing up, dry mouth, headache, nausea, and a stuffy nose. Rarely, vivid dreams.
Call the office the same day if
- An erection that lasts more than four hours or is painful (go to the emergency room; this is rare but needs immediate treatment)
- Fainting or a very slow or irregular heartbeat
- Fever with agitation, muscle twitching, or confusion, especially with an antidepressant (possible serotonin syndrome)
- New or worsening thoughts of hurting yourself
- Rash, swelling, or trouble breathing (call 911)
Stopping
At sleep doses, trazodone can usually be stopped without much trouble, though sleep may be lighter for a few nights. At antidepressant doses, we taper gradually. Tell us before stopping.
Good to know
- Stand up slowly at night; dizziness on standing is the most common reason for falls.
- Avoid alcohol and other sedatives on the same night.
- Tell other prescribers and your pharmacist, especially about other antidepressants and medicines that affect heart rhythm.
Questions about this medication?
Alice Tran Psychiatric Care · 3060 Williams Drive, Suite 300, Fairfax, VA 22031
Call: (703) 791-9099 · Text: (703) 791-9031 · info@alicetrannp.com · alicetrannp.com
This handout is for education and is not a substitute for the instructions you received at your visit. Follow the dose on your prescription label. If anything here differs from what you were told, call the office. In an emergency, call 911. If you are in crisis, call or text 988.