Patient handout
Bupropion (Wellbutrin)
You have been prescribed bupropion. This page explains what it is, what to expect, and when to call.
What it is
Bupropion is an antidepressant that works on dopamine and norepinephrine rather than serotonin. It is used for depression, seasonal depression, and to help stop smoking, and is sometimes added to another antidepressant. It tends not to cause sexual side effects or weight gain. It does not treat anxiety on its own and can feel activating.
How to take it
- Take it in the morning. Taken late in the day it can keep you awake.
- Extended-release (XL) is once a day; sustained-release (SR) is usually twice a day, at least eight hours apart. Swallow tablets whole; do not crush or split them.
- If you miss a dose, skip it and take the next one on time. Never double up; higher single doses raise the risk of seizure.
- Take it with food if it upsets your stomach.
What to expect, and when
- Week 1 to 2: dry mouth, trouble sleeping, or feeling keyed up are the most common early effects.
- Week 2 to 4: energy, motivation, and concentration often improve first.
- Week 4 to 8: full benefit at the right dose.
- Plan to stay on it for at least six to twelve months after you feel well.
Common side effects
Dry mouth, trouble sleeping, headache, nausea, sweating, mild tremor, constipation, and reduced appetite. Some people feel more anxious or irritable at first. Blood pressure can rise slightly, so we check it.
Call the office the same day if
- A seizure, fainting, or a blackout (call 911)
- New or worsening thoughts of hurting yourself, especially early on or after a dose change (particularly under age 25)
- Severe agitation, panic, or feeling unable to sit still
- Rash, hives, swelling, or trouble breathing (call 911)
- Markedly elevated blood pressure or chest pain
Stopping
Bupropion is easier to stop than SSRIs, but do not stop on your own. Tell us so the change is planned and your mood is watched.
Good to know
- Do not take bupropion if you have a seizure disorder, an eating disorder such as anorexia or bulimia, or are stopping heavy alcohol or benzodiazepine use abruptly. Tell us if any of these apply.
- Keep alcohol light and steady; heavy drinking or sudden stopping raises seizure risk.
- Tell other prescribers and your pharmacist. Bupropion interacts with some medicines, including certain antidepressants, antipsychotics, and beta-blockers.
Questions about this medication?
Alice Tran Psychiatric Care · 3060 Williams Drive, Suite 300, Fairfax, VA 22031
Call: (703) 791-9099 · Text: (703) 791-9031 · info@alicetrannp.com · alicetrannp.com
This handout is for education and is not a substitute for the instructions you received at your visit. Follow the dose on your prescription label. If anything here differs from what you were told, call the office. In an emergency, call 911. If you are in crisis, call or text 988.